Oils containing the omega-6 fatty acid gamma linolenic acid (GLA), such as borage oil, black currant seed oil and evening primrose oil (EPO), have also been reported to be effective in the treatment of RA. The most pronounced effects were seen with borage oil.
GLA appears to be effective because it is converted in part to prostaglandin E1, a compound known to have anti-inflammatory activity. Supplementation with GLA often allows a patient to reduce their dosage of non-steroidal anti-inflammatory drugs (NSAIDs). Furthermore, animal studies show that GLA protects the stomach lining against gastric acid, reducing the side effects of prescription and over-the-counter NSAIDs, such as aspirin. GLA is therefore useful in conjunction with conventional arthritis medications.
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